Surgical Intervention to Rescue Hirschsprung Disease in a Rat Model

Surgical Intervention to Rescue Hirschsprung Disease in a Rat Model

BACKGROUND/AIMS Rats with a spontaneous null mutation in endothelin receptor type B or Ednrb (sl/sl; spotting lethal) lack enteric neurons in the distal bowel and usually die within the first week after birth. This early postnatal lethality limits their use for examining the potential of cell therapy to treat Hirschsprung disease, and for studies of the influence of EDNRB on the mature CNS and ...

Hepatorenal Repercussions of Alcoholic Exposure in a Rat Model: a Dose-Dependent Study of Metformin Intervention

Background: Diabetes mellitus is an alarming life style disease in the modern world. Exploitation of the anti-diabetic drugs for the amelioration of diabetes and associated life style diseases has become an imperative concern. In this milieu, this study was designed to explore the plausible effects of metformin intervention on hepatic and renal functions in a rat model of alcoholic liver diseas...

Neuroprotective effect of quercetin in a model of Parkinson’s disease in rat: A histochemical analysis

AbstractIntroduction: Parkinson's disease (PD) is a neuropathological disorder involving the degeneration of dopaminergic neurons in the substantia nigra, with the subsequent loss of their terminals in the striatum. Quercetin, a natural flavonoid, is a strong antioxidant and radical scavenger. Therefore, its neuroprotective effect in a model of Parkinson’s disease in rat was evaluated.Methods: ...

Antibacterial Activity of Origanum vulgare on Staphylococcus aureus in a Rat Model of Surgical Wound Infection

A Business Model to Detect Disease Outbreaks

Introduction: Every year several disease outbreaks, such as influenza-like illnesses (ILI) and other contagious illnesses, impose various costs to public and non-government agencies. Most of these expenses are due to not being ready to handle such disease outbreaks. An appropriate preparation will reduce the expenses. A system that is able to recognize these outbreaks can earn ...